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. 2003 Aug;66(8):1097-100.
doi: 10.1021/np030044w.

A novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile

Andrea A Stierle  1 , Donald B Stierle, Eric Goldstein, Keith Parker, Tim Bugni, Chad Baarson, Julie Gress, Danielle Blake
Affiliations

A novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile

Andrea A Stierle et al. J Nat Prod. 2003 Aug.

Abstract

Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich in toxic metals. A Pithomycessp. isolated from the Pit Lake yielded three tyrosine derivatives (1-3), one of which acts as a 5-HT((2a)) receptor ligand. This type of activity has been associated with migraine preventative and antihypertensive drugs. The isolation and characterization of compounds 1-3 and three sesquiterpenes (5-7) that have been isolated previously from higher plants are reported here.

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