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. 2003 Jul-Aug;38(7-8):769-73.
doi: 10.1016/s0223-5234(03)00127-2.

Synthesis of 4-octyl-2H-1,4-benzo-thiazin-3-ones

Vera L de M Guarda  1 , Monique Perrissin, François Thomasson, Eulalia A Ximenes, Suely L Galdino, Ivan R Pitta, Cuong Luu-Duc, Jacques Barbe
Affiliations

Synthesis of 4-octyl-2H-1,4-benzo-thiazin-3-ones

Vera L de M Guarda et al. Eur J Med Chem. 2003 Jul-Aug.

Abstract

Synthesis, physical and analytical properties of 6-alkylacylamino-4-octyl-2H-1,4-benzo-thiazin-3-ones derivatives are described. These new compounds were prepared by acylation and/or alkylation of the amino group under phase transfer catalysis conditions. Acid hydrolysis of the alkylacylamino-2H-1,4-benzo-thiazin-3-ones afforded N-alkylamino-benzothiazin-3-ones. Some of these compounds were evaluated in vitro for possible bacteriostatic activity.

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