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. 1976 Jan 15;32(1):77-9.
doi: 10.1007/BF01932633.

The (Na+ + K+)-ATPase activity in brain of Quaking mice

P Mandel, V Stefanovic, J C Hermetet, A Ebel

The (Na+ + K+)-ATPase activity in brain of Quaking mice

P Mandel et al. Experientia. .

Abstract

The (Na+ 4 K+)- and Mg2+-dependent ATPase distribution in several brain areas has been investigated in Quaking mutant mice characterized by myelin deficiency. A marked decrease of (Na+ + K+)-ATPase activity has been found in limbic structures, hypothalamus and cerebellum. The Mg2+-dependent activity did not change. A possible involvement of the impairment of the (Na+ + K+)-ATPase activity in the seizure susceptibility of this mice is discussed.

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