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. 2002 Jun;3(2):245-65.
doi: 10.1093/biostatistics/3.2.245.

Strategies to fit pattern-mixture models

Herbert Thijs  1 , Geert Molenberghs, Bart Michiels, Geert Verbeke, Desmond Curran
Affiliations

Strategies to fit pattern-mixture models

Herbert Thijs et al. Biostatistics. 2002 Jun.

Abstract

Whereas most models for incomplete longitudinal data are formulated within the selection model framework, pattern-mixture models have gained considerable interest in recent years (Little, 1993, 1994). In this paper, we outline several strategies to fit pattern-mixture models, including the so-called identifying restrictions strategy. Multiple imputation is used to apply this strategy to realistic settings, such as quality-of-life data from a longitudinal study on metastatic breast cancer patients.

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