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Clinical Trial
. 2003 Sep;47(9):2987-9.
doi: 10.1128/AAC.47.9.2987-2989.2003.

Measurement of cefaclor and amoxicillin-clavulanic acid levels in middle-ear fluid in patients with acute otitis media

F Scaglione  1 , D Caronzolo, J P Pintucci, F Fraschini
Affiliations
Clinical Trial

Measurement of cefaclor and amoxicillin-clavulanic acid levels in middle-ear fluid in patients with acute otitis media

F Scaglione et al. Antimicrob Agents Chemother. 2003 Sep.

Abstract

Concentrations of cefaclor (CFC) or amoxicillin-clavulanic acid (AMX/CA) in middle-ear fluid collected preserving the stability and clearing the cell contents has been compared to those obtained using the traditional method. Sixty-seven children with effusive otitis media were treated orally with CFC (20 mg/kg of body weight) or AMX/CA (20 mg/kg) (4:1 ratio). The concentrations in cell-free fluid (C-) appear higher than those in the total fluid (C+) (as assayed traditionally).

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Figures

FIG. 1.
FIG. 1.
Cefaclor concentrations in C+ and C− middle-ear fluid (P < 0.001).
FIG. 2.
FIG. 2.
Amoxicillin (a) and Clavulanic acid (b) concentrations in C+ and C− middle-ear fluid (for amoxicillin, P = 0.005; for clavulanic acid, P = 0.022).
See this image and copyright information in PMC

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