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Comparative Study
. 2003 Sep;47(9):3002-4.
doi: 10.1128/AAC.47.9.3002-3004.2003.

Efficacy of linezolid alone or in combination with vancomycin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus

Fu-Yu Chiang  1 , Michael Climo
Affiliations
Comparative Study

Efficacy of linezolid alone or in combination with vancomycin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus

Fu-Yu Chiang et al. Antimicrob Agents Chemother. 2003 Sep.

Abstract

The levels of effectiveness of linezolid, vancomycin, and the combination of linezolid and vancomycin were compared in the rabbit model of endocarditis caused by a clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate. Vancomycin alone was more effective than either linezolid alone or the combination of linezolid and vancomycin for the treatment of endocarditis due to MRSA.

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