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. 2003 Sep;47(9):3008-11.
doi: 10.1128/AAC.47.9.3008-3011.2003.

In vitro activities of ABT-492, a new fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis

Ellie J C Goldstein  1 , Diane M Citron, C Vreni Merriam, Yumi A Warren, Kerin L Tyrrell, Helen T Fernandez
Affiliations

In vitro activities of ABT-492, a new fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis

Ellie J C Goldstein et al. Antimicrob Agents Chemother. 2003 Sep.

Abstract

ABT-492 exhibited excellent in vitro activities against all 326 aerobic and anaerobic antral puncture sinus isolates tested with MICs (in micrograms per milliliter) at which 90% of the isolates tested were inhibited as follows: Haemophilus influenzae, 0.001; Moraxella catarrhalis, 0.008; and Streptococcus pneumoniae, 0.015. It was four- to sixfold more active than other fluoroquinolones, including against levofloxacin-resistant strains of S. pneumoniae, methicillin-resistant Staphylococcus aureus, and Prevotella species.

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References

    1. Brook, I. 2002. Anaerobic bacteria in upper respiratory tract and other head and neck infections. Ann. Otol. Rhinol. Laryngol. 111:430-440. - PubMed
    1. Brueggemann, A. B., S. L. Coffman, P. Rhomberg, H. Huynh, L. Almer, A. Nilius, R. Flamm, and G. V. Doern. 2002. Fluoroquinolone resistance in Streptococcus pneumoniae in United States since 1994-1995. Antimicrob. Agents Chemother. 46:680-688. - PMC - PubMed
    1. Finegold, S. M., M. J. Flynn, F. V. Rose, H. Jousimies-Somer, C. Jakielaszek, M. McTeague, H. M. Wexler, E. Berkowitz, and B. Wynne. 2002. Bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults. Clin. Infect. Dis. 35:428-433. - PubMed
    1. Goldstein, E. J. C., and S. M. Garabedian-Ruffalo. 2002. Widespread use of fluoroquinolones versus emerging resistance of pneumococci. Clin. Infect. Dis. 35:1505-1511. - PubMed
    1. Goldstein, E. J. C., D. M. Citron, and C. V. Merriam. 1999. Comparative in vitro activities of amoxicillin-clavulanate against aerobic and anaerobic bacteria isolated from antral puncture specimens from patients with sinusitis. Antimicrob. Agents Chemother. 43:705-707. - PMC - PubMed

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