doi: 10.1023/a:1025437620749.
Mammary tumors in HER-2/NEU mice are characterized by low content of estrogen receptors-alpha and absence of progesterone receptors
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- PMID: 12937679
- DOI: 10.1023/a:1025437620749
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Mammary tumors in HER-2/NEU mice are characterized by low content of estrogen receptors-alpha and absence of progesterone receptors
Bull Exp Biol Med.
2003 Jun.
Abstract
Transgenic mice carrying erbB2(HER-2)neu gene are characterized by high incidence of mammary adenocarcinoma. The content of estrogen receptor was no more than 10 fmol/mg protein in 8 of 14 studied tumors, while the content of progesterone receptors was even lower in all 14 studied tumors. Based on these data, we distinguish two subtypes of HER-2/neu-adenocarcinomas in mice: ER+,PR- and ER-,PR-, which can be used for the development of new approaches to the treatment of receptor-negative mammary gland tumors.
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