Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Nov 1;375(Pt 3):517-29.
doi: 10.1042/BJ20031061.

Regulation and organization of adenylyl cyclases and cAMP

Dermot M F Cooper  1
Affiliations
Review

Regulation and organization of adenylyl cyclases and cAMP

Dermot M F Cooper. Biochem J. .

Abstract

Adenylyl cyclases are a critically important family of multiply regulated signalling molecules. Their susceptibility to many modes of regulation allows them to integrate the activities of a variety of signalling pathways. However, this property brings with it the problem of imparting specificity and discrimination. Recent studies are revealing the range of strategies utilized by the cyclases to solve this problem. Microdomains are a consequence of these solutions, in which cAMP dynamics may differ from the broad cytosol. Currently evolving methodologies are beginning to reveal cAMP fluctuations in these various compartments.

PubMed Disclaimer

References

    1. J Biol Chem. 1993 Mar 5;268(7):4604-7 - PubMed
    1. Trends Pharmacol Sci. 1993 Feb;14(2):34-6 - PubMed
    1. Biochemistry. 1993 Jun 15;32(23):6081-8 - PubMed
    1. Synapse. 1993 May;14(1):51-9 - PubMed
    1. Mol Pharmacol. 1993 Jul;44(1):158-65 - PubMed

Publication types