Physiology and biophysics of hemi-gap-junctional channels expressed in Xenopus oocytes

Abstract

Gap junctional channels are intercellular channels that allow the passage of ions and other small molecules less than about 1 kD in size between neighbouring cells. They are composed of two oligomeric protein subunits called connexons or hemichannels which reside in the plasma membrane of closely opposed cells. Several recent studies suggest that unpaired connexons may be active on the non-junctional plasma membrane of cells. Here I present a short overview of the properties of connexon channels expressed in Xenopus oocytes.