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Comment
. 2003 Aug 22;114(4):398-9.
doi: 10.1016/s0092-8674(03)00649-4.

Cell proliferation without cyclin E-CDK2

Juan Méndez  1
Affiliations
Free article
Comment

Cell proliferation without cyclin E-CDK2

Juan Méndez. Cell. .
Free article

Abstract

In this issue of Cell, Geng et al. report that mice can undergo embryonic development without cyclins E1 and E2. Fibroblasts derived from the double knockout embryos proliferate normally in culture. However, E type cyclins seem essential for endoreplication and exit from quiescence.

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  • Cyclin E ablation in the mouse.
    Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S, Rideout WM, Bronson RT, Gardner H, Sicinski P. Geng Y, et al. Cell. 2003 Aug 22;114(4):431-43. doi: 10.1016/s0092-8674(03)00645-7. Cell. 2003. PMID: 12941272

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