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Review
. 2003 Sep;77(18):9733-7.
doi: 10.1128/jvi.77.18.9733-9737.2003.

Ebola virus pathogenesis: implications for vaccines and therapies

Nancy Sullivan  1 , Zhi-Yong Yang, Gary J Nabel
Affiliations
Review

Ebola virus pathogenesis: implications for vaccines and therapies

Nancy Sullivan et al. J Virol. 2003 Sep.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Host immune responses to Ebola virus and cell damage due to direct infection of monocytes and macrophages cause the release of cytokines associated with inflammation and fever (A). Infection of endothelial cells also induces a cytopathic effect and damage to the endothelial barrier that, together with cytokine effects, leads to the loss of vascular integrity (B). Transient expression of Ebola virus GP in human umbilical vein endothelial cells or 293T cells causes a reduction of specific integrins (primary molecules responsible for cell adhesion to the extracellular matrix) and immune molecules on the cell surface. Cytokine dysregulation and virus infection may synergize at the endothelial surface, promoting hemorrhage and vasomotor collapse.
See this image and copyright information in PMC

References

    1. Alvarez, C. P., F. Lasala, J. Carrillo, A. L. Corbi, and R. Delgado. 2002. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J. Virol. 76:6841-6844. - PMC - PubMed
    1. Baize, S., E. M. Leroy, M.-C. Georges-Courbot, M. Capron, J. Lansoud-Soukate, P. Debre, S. P. Fisher-Hoch, J. B. McCormick, and A. J. Georges. 1999. Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients. Nat. Med. 5:423-426. - PubMed
    1. Baskerville, A., E. T. W. Bowen, G. S. Platt, L. B. McArdell, and D. I. H. Simpson. 1978. The pathology of experimental Ebola virus infection in monkeys. J. Pathol. 125:131-138. - PubMed
    1. Baskerville, A., S. P. Fisher-Hoch, G. H. Neild, and A. B. Dowsett. 1985. Ultrastructural pathology of experimental Ebola haemorrhagic fever virus infection. J. Pathol. 147:199-209. - PubMed
    1. Basler, C. F., X. Wang, E. Muhlberger, V. Volchkov, J. Paragas, H.-D. Klenk, A. Garcia-Sastre, and P. Palese. 2000. The Ebola virus VP35 protein functions as a type 1 IFN antagonist. Proc. Natl. Acad. Sci. USA 97:12289-12294. - PMC - PubMed

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