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. 2003 Sep 1;89(5):864-9.
doi: 10.1038/sj.bjc.6601199.

Prognostic value of genomic alterations in head and neck squamous cell carcinoma detected by comparative genomic hybridisation

J N E Ashman  1 , H S Patmore, L T Condon, L Cawkwell, N D Stafford, J Greenman
Affiliations

Prognostic value of genomic alterations in head and neck squamous cell carcinoma detected by comparative genomic hybridisation

J N E Ashman et al. Br J Cancer. .

Abstract

A total of 45 primary head and neck squamous cell carcinomas were analysed by comparative genomic hybridisation to identify regions of chromosomal deletion and gain. Multiple regions of copy number aberration were identified including gains affecting chromosomes 3q, 8q, 5p, 7q, 12p and 11q and deletion of material from chromosomes 3p, 11q, 4p, 5q, 8p, 10q, 13q and 21. Kaplan-Meier survival analysis revealed significant correlations between gain of 3q25-27 and deletion of 22q with reduced disease-specific survival. In addition, gain of 17q and 20q, deletion of 19p and 22q and amplification of 11q13 were significantly associated with reduced disease-free survival. A Cox proportional hazards regression model identified deletion of 22q as an independent prognostic marker. The data presented here provide further evidence that the creation of a genetically based tumour classification system will soon be possible, complementing current histopathological characterisation.

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Figures

Figure 1
Figure 1
Summary of all chromosomal gains and losses identified in 45 primary HNSCC tumours by CGH. Lines to the left of the chromosome ideograms represent regions of deletion and lines to the right represent gains. The relative lengths of each line represents the size of the region of gain or loss. All CGH ratio deviations identified using the thresholds detailed in the methods were included. A few, particularly small, regions of copy number change below the accepted resolution of CGH (∼10 Mb) are present and care should be taken in interpreting these.
Figure 2
Figure 2
Kaplan–Meier survival curves for disease-specific survival in tumours demonstrating (A) tumours with pathologically proven nodal involvement at time of surgery, (B) gains specifically within the region 3q25–q27, (C) gains on 3q and (D) deletion of 22q. Dotted lines represent tumours that exhibited the chromosomal imbalance (or nodal involvement in the case of A) and solid lines represent those that did not. Crosses indicate censored cases (patients alive at time of analysis).
See this image and copyright information in PMC

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