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. 1976 Feb 29;31(2):197-202.
doi: 10.1007/BF00296146.

Dosage effect of SOD-A gene in 21-trisomic cells

N Crosti, A Serra, A Rigo, P Viglino

Dosage effect of SOD-A gene in 21-trisomic cells

N Crosti et al. Hum Genet. .

Abstract

SOD-A activity was measured by the polarographic method of catalytic currents in 30 subjects 10-24 years of age with a karyotype 47, + 21, and 30 age matched normal subjects. The ratio of the average amount of SOD-A in 21-trisomic cells to the average amount in normal cells is 1.4495. Statistical analysis confirms that this ratio does not differ significantly from the ratio 1.5 expected in the case of a simple gene dosage effect.

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