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. 2003 Sep 4;5(18):3273-5.
doi: 10.1021/ol035138b.

Enantioselective synthesis of propargylamines through Zr-catalyzed addition of mixed alkynylzinc reagents to arylimines

John F Traverse  1 , Amir H Hoveyda, Marc L Snapper
Affiliations

Enantioselective synthesis of propargylamines through Zr-catalyzed addition of mixed alkynylzinc reagents to arylimines

John F Traverse et al. Org Lett. .

Abstract

[reaction: see text] Addition of mixed alkynylzinc reagents to various arylimines is catalyzed by chiral amino acid-based ligand 1 and Zr(Oi-Pr)(4).HOi-Pr to afford chiral propargylamines in up to 90% ee. Oxidative removal of the o-anisidyl group affords the free amine, which can then be acylated.

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