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. 2003 Sep 4;5(18):3305-8.
doi: 10.1021/ol030085j.

Use of bis-(chiral alpha-methylbenzyl)glycine esters for synthesis of enantiopure beta-hydroxyamino esters

Ayako Yamashita  1 , Emily B Norton, R Thomas Williamson, Douglas M Ho, Sandra Sinishtaj, Tarek S Mansour
Affiliations

Use of bis-(chiral alpha-methylbenzyl)glycine esters for synthesis of enantiopure beta-hydroxyamino esters

Ayako Yamashita et al. Org Lett. .

Abstract

[reaction: see text] Aldol reactions using bis-(chiral alpha-methylbenzyl)glycine esters with aldehydes gave excellent diastereoselectivity. Thus, an enantiopure ribosylglycine was prepared for the synthesis of analogues of the natural antibiotics muraymycin. This method was extended for formation of beta-hydroxyamino esters.

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