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. 2003 Sep 1;92(5):628-31.
doi: 10.1016/s0002-9149(03)00741-0.

Biological variation for N-terminal pro- and B-type natriuretic peptides and implications for therapeutic monitoring of patients with congestive heart failure

Alan H B Wu  1 , Andrew Smith, Stacey Wieczorek, Jeffrey F Mather, Bret Duncan, C Michael White, Carol McGill, Deb Katten, Gary Heller
Affiliations

Biological variation for N-terminal pro- and B-type natriuretic peptides and implications for therapeutic monitoring of patients with congestive heart failure

Alan H B Wu et al. Am J Cardiol. .

Abstract

Given the limitations of low enrollments, this study suggests that a change of 130% for B-type natiuretic peptide (BNP) and 90% for N-terminal (NT)-proBNP are necessary before results of serially collected data can be considered statistically different. This study also shows that there are important differences in the performance of BNP versus NT-proBNP in monitoring patients with congestive heart failure that need to be further explored.

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