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. 2003 Aug 28;22(36):5707-11.
doi: 10.1038/sj.onc.1206800.

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

Satoshi Kanazawa  1 , Laura Soucek, Gerard Evan, Takashi Okamoto, B Matija Peterlin
Affiliations

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

Satoshi Kanazawa et al. Oncogene. .

Abstract

c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II, which is required for the transition from initiation to elongation of eukaryotic transcription. Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc.

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