NMR-based screening technologies
- PMID: 12946643
- DOI: 10.1016/s1359-6446(03)02796-x
NMR-based screening technologies
Abstract
NMR-based ligand screening is now an established field in its own right. In recent years, advances in both methodology and hardware have broadened its range of applications and pushed back practical limitations, leading to the growing importance of NMR screening as a tool in industrial drug research. An overview of new screening methods and applications is presented here, and ways in which NMR-screening is being used in cooperation with other screening techniques are discussed.
Similar articles
-
Application of NMR screening in drug discovery.Curr Top Med Chem. 2003;3(1):81-97. doi: 10.2174/1568026033392796. Curr Top Med Chem. 2003. PMID: 12570779 Review.
-
ID NMR Methods in ligand-receptor interactions.Curr Top Med Chem. 2003;3(1):25-37. doi: 10.2174/1568026033392750. Curr Top Med Chem. 2003. PMID: 12577989 Review.
-
Automation of biomolecular NMR screening.Curr Top Med Chem. 2003;3(1):55-67. doi: 10.2174/1568026033392688. Curr Top Med Chem. 2003. PMID: 12570777 Review.
-
Structure-based screening and design in drug discovery.Drug Discov Today. 2002 Apr 15;7(8):471-8. doi: 10.1016/s1359-6446(02)02233-x. Drug Discov Today. 2002. PMID: 11965396 Review.
-
Second-site NMR screening and linker design.Curr Top Med Chem. 2003;3(1):69-80. doi: 10.2174/1568026033392778. Curr Top Med Chem. 2003. PMID: 12570778 Review.
Cited by
-
(1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein.J Biomol NMR. 2004 Sep;30(1):111-2. doi: 10.1023/B:JNMR.0000042953.83397.8e. J Biomol NMR. 2004. PMID: 15452444 No abstract available.
-
Biophysical characterization of recombinant proteins: a key to higher structural genomics success.J Struct Biol. 2010 Oct;172(1):107-19. doi: 10.1016/j.jsb.2010.05.005. Epub 2010 May 11. J Struct Biol. 2010. PMID: 20466062 Free PMC article. Review.
-
Estimating protein-ligand binding affinity using high-throughput screening by NMR.J Comb Chem. 2008 Nov-Dec;10(6):948-58. doi: 10.1021/cc800122m. Epub 2008 Oct 3. J Comb Chem. 2008. PMID: 18831571 Free PMC article.
-
NMR-based exploration of the acceptor binding site of human blood group B galactosyltransferase with molecular fragments.Glycoconj J. 2010 Apr;27(3):349-58. doi: 10.1007/s10719-010-9282-5. Epub 2010 Mar 9. Glycoconj J. 2010. PMID: 20217221
-
High-field solution NMR spectroscopy as a tool for assessing protein interactions with small molecule ligands.J Pharm Sci. 2008 Nov;97(11):4670-95. doi: 10.1002/jps.21378. J Pharm Sci. 2008. PMID: 18351634 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical