Review
doi: 10.1385/IR:28:1:39.
Immune regulation by novel costimulatory molecules
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- PMID: 12947223
- DOI: 10.1385/IR:28:1:39
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Review
Immune regulation by novel costimulatory molecules
Immunol Res.
2003.
Abstract
CD4 helper T (Th)-cells and the cytokines that they produce play essential regulatory roles in immune and autoimmune responses. Th activation and differentiation is regulated by costimulatory receptors. CD28 and CTLA-4 are important in maintaining the threshold of T-cell activation. ICOS and PD-1 are novel costimulatory receptors expressed on activated T-cells. B7-H3 recognizes a putative costimulatory receptor on activated T-cells. Here we summarize the latest developments in the novel costimulatory molecules and their roles in regulating Th activation, differentiation, and function.
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