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. 2003 Aug;20(8):1284-92.
doi: 10.1023/a:1025017502379.

Novel polyester-polysaccharide nanoparticles

Caroline Lemarchand  1 , Patrick Couvreur, Madeleine Besnard, Dominique Costantini, Ruxandra Gref
Affiliations

Novel polyester-polysaccharide nanoparticles

Caroline Lemarchand et al. Pharm Res. 2003 Aug.

Abstract

Purpose: The aim of the present study was to develop a new type of core-shell nanoparticles from a family of novel amphiphilic copolymers, based on dextran (DEX) grafted with poly(epsilon-caprolactone) (PCL) side chains (PCL-DEX).

Methods: A family of PCL-DEX copolymers was synthesized in which both the molecular weight and the proportion by weight of DEX in the copolymer were varied. The nanoparticles were prepared by a technique derived from emulsion-solvent evaporation, during which emulsion stability was investigated using a Turbiscan. The nanoparticle size distribution, density, zeta potential, morphology, and suitability for freeze-drying were determined.

Results: Because of their strongly amphiphilic properties, the PCL-DEX copolymers were able to stabilize o/w emulsions without the need of additional surfactants. Nanoparticles with a controlled mean diameter ranging from 100 to 250 nm were successfully prepared. A mechanism of formation of these nanoparticles was proposed. Zeta potential measurements confirmed the presence of a DEX coating.

Conclusion: A new generation of polysaccharide-decorated nanoparticles has been successfully prepared from a family of PCL-DEX amphiphilic copolymers. They may have potential applications in drug encapsulation and targeting.

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