Review
doi: 10.1016/s0896-6273(03)00528-2.
A tale of timing and transport
Affiliations
- PMID: 12948438
- DOI: 10.1016/s0896-6273(03)00528-2
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Review
A tale of timing and transport
Neuron.
.
Free article
Abstract
Excitatory and inhibitory synapses show long-term plasticity, but spike timing-dependent plasticity was seen only at excitatory connections. No longer. In this issue of Neuron, Woodin et al. demonstrate that coincident pre- and postsynaptic activity acts on the neuronal K+/Cl- cotransporter KCC2 to shift the reversal potential for Cl- and thus alters the effectiveness of GABAergic synapses.
Comment on
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Coincident pre- and postsynaptic activity modifies GABAergic synapses by postsynaptic changes in Cl- transporter activity.Neuron. 2003 Aug 28;39(5):807-20. doi: 10.1016/s0896-6273(03)00507-5. Neuron. 2003. PMID: 12948447
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