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. 2003 Sep;10(5):596-601.
doi: 10.1016/s0967-5868(03)00142-5.

Effects of immunonutrition on intestinal mucosal apoptosis, mucosal atrophy, and bacterial translocation in head injured rats

Hulya Ulusoy  1 , Haydar Usul, Sevim Aydin, Nese Kaklikkaya, Umit Cobanoglu, Abdulkadir Reis, Ahmet Akyol, Ibrahim Ozen
Affiliations

Effects of immunonutrition on intestinal mucosal apoptosis, mucosal atrophy, and bacterial translocation in head injured rats

Hulya Ulusoy et al. J Clin Neurosci. 2003 Sep.

Abstract

Background: Immunonutrition has been demonstrated to modulate gut function, reduce infectious complications, hospital stay, and ventilator days in the critical patients.

Aim of the study: We assessed the effect of immunonutrition for the prevention of intestinal mucosal atrophy, apoptosis, and bacterial translocation in head injured rats.

Methods: Thirty five rats were randomised into 5 groups. Following moderate closed head injury, in Group 1; Standard Enteral Nutrition, Group 2; Immunonutrition, Group 3; TPN, Group 4; pe. saline were applied. Group 5 was control group (chow-fed). The rats were sacrificed and segments of the ileum were removed for histologic examination, and samples of tissues taken for microbiologic evaluation.

Results: Both intestinal apoptosis and mucosal atrophy were significantly lower in Group 2 and Group 5 (p<0.008). Bacterial translocation was significantly lower in Group 2 than Group 1 (p<0.008).

Conclusion: The enteral immunonutrition prevents intestinal barrier function in brain injured rats.

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