Review
doi: 10.1038/nri1178.
Reassessing the function of immune-complex retention by follicular dendritic cells
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- PMID: 12949499
- DOI: 10.1038/nri1178
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Review
Reassessing the function of immune-complex retention by follicular dendritic cells
Nat Rev Immunol.
2003 Sep.
Abstract
The close association of follicular dendritic cells (FDCs) and germinal-centre B cells has fostered the idea that B-cell recognition of retained antigen that is presented on the surface of FDCs is important for affinity maturation and memory B-cell development. We argue that the retention of immune complexes is not required for germinal-centre development, affinity maturation and memory B-cell maintenance. Instead, it is probable that FDCs support B-cell proliferation and differentiation in a non-specific manner. Other potential roles of immune complexes retained by FDCs are discussed.
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