Review
doi: 10.1038/nri1179.
Are follicular dendritic cells really good for nothing?
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- PMID: 12949500
- DOI: 10.1038/nri1179
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Review
Are follicular dendritic cells really good for nothing?
Nat Rev Immunol.
2003 Sep.
Abstract
Follicular dendritic cells (FDCs), which reside in the primary B-cell follicles and germinal centres of lymphoid tissues, can sequester antigen in the form of immune complexes and are thought to be pivotal to the germinal-centre reaction and the maintenance of immunological memory. But, many recent studies question the importance of FDCs and their bound immune complexes in B-cell responses. This article asks whether we can truly rule out a requirement for these cells in host defence.
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