Taming transplantation with T cells

Comment

Shimon Sakaguchi. Nat Med. 2003 Sep.

. 2003 Sep;9(9):1117-8.

doi: 10.1038/nm0903-1117.

No abstract available

Comment on

CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation.
Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, Strober S, Negrin RS. Edinger M, et al. Nat Med. 2003 Sep;9(9):1144-50. doi: 10.1038/nm915. Epub 2003 Aug 17. Nat Med. 2003. PMID: 12925844

Suppression of graft-versus-host disease by naturally occurring regulatory T cells.
Zeng D, Lan F, Hoffmann P, Strober S. Zeng D, et al. Transplantation. 2004 Jan 15;77(1 Suppl):S9-S11. doi: 10.1097/01.TP.0000106475.38978.11. Transplantation. 2004. PMID: 14726761 Review.
Donor antigen-presenting cells regulate T-cell expansion and antitumor activity after allogeneic bone marrow transplantation.
Li JM, Waller EK. Li JM, et al. Biol Blood Marrow Transplant. 2004 Aug;10(8):540-51. doi: 10.1016/j.bbmt.2004.05.007. Biol Blood Marrow Transplant. 2004. PMID: 15282532
A new strategy for treatment of malignant tumor: intra-bone marrow-bone marrow transplantation plus CD4- donor lymphocyte infusion.
Suzuki Y, Adachi Y, Minamino K, Zhang Y, Iwasaki M, Nakano K, Koike Y, Ikehara S. Suzuki Y, et al. Stem Cells. 2005 Mar;23(3):365-70. doi: 10.1634/stemcells.2004-0258. Stem Cells. 2005. PMID: 15749931
Selective elimination of alloreactive donor T cells attenuates graft-versus-host disease and enhances T-cell reconstitution.
Gendelman M, Yassai M, Tivol E, Krueger A, Gorski J, Drobyski WR. Gendelman M, et al. Biol Blood Marrow Transplant. 2003 Dec;9(12):742-52. doi: 10.1016/j.bbmt.2003.09.007. Biol Blood Marrow Transplant. 2003. PMID: 14677113
Regulatory T cells.
Blazar BR, Taylor PA. Blazar BR, et al. Biol Blood Marrow Transplant. 2005 Feb;11(2 Suppl 2):46-9. doi: 10.1016/j.bbmt.2004.11.005. Biol Blood Marrow Transplant. 2005. PMID: 15682177 Review. No abstract available.

Adult thymus transplantation with allogeneic intra-bone marrow-bone marrow transplantation from same donor induces high thymopoiesis, mild graft-versus-host reaction and strong graft-versus-tumour effects.
Miyake T, Hosaka N, Cui W, Nishida T, Takaki T, Inaba M, Kamiyama Y, Ikehara S. Miyake T, et al. Immunology. 2009 Apr;126(4):552-64. doi: 10.1111/j.1365-2567.2008.02920.x. Epub 2008 Sep 4. Immunology. 2009. PMID: 18778285 Free PMC article.