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Case Reports
. 2003 Sep;28(5):496-8.
doi: 10.1046/j.1365-2230.2003.01336.x.

A near fatal case of the dapsone hypersensitivity syndrome in a patient with urticarial vasculitis

K S Leslie  1 , K Gaffney, C N Ross, S Ridley, T H Barker, J J Garioch
Affiliations
Case Reports

A near fatal case of the dapsone hypersensitivity syndrome in a patient with urticarial vasculitis

K S Leslie et al. Clin Exp Dermatol. 2003 Sep.

Abstract

Dapsone (4,4'-diaminodiphenyl sulphone) is used for a variety of dermatological conditions including immunobullous diseases and urticarial vasculitis. Side-effects are common and include lethargy, headaches, methaemoglobinaemia and haemolysis. Severe adverse effects are rare but the dapsone hypersensitivity syndrome is well recognized. Symptoms include fever, haemolytic anaemia, lymphocytosis and hepatitis. We report a near fatal case of the dapsone hypersensitivity syndrome in a patient with urticarial vasculitis. This diagnosis should be remembered in any patient who becomes unwell whilst taking dapsone.

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