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Clinical Trial
. 2003 Oct;57(5):542-4.
doi: 10.1046/j.1440-1819.2003.01161.x.

Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients

Maher Karam-Hage  1 , Kirk J Brower
Affiliations
Clinical Trial

Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients

Maher Karam-Hage et al. Psychiatry Clin Neurosci. 2003 Oct.

Abstract

Alcohol-dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4-6 weeks on medication using the Sleep Problems Questionnaire (SPQ). Of 55 cases initially treated, 9% dropped out due to morning drowsiness. Of the remaining 50 cases, 34 were treated with gabapentin (mean dose +/- SD = 888 +/- 418 mg) at bedtime and 16 were treated with trazodone (105 +/- 57 mg) at bedtime. Both groups improved significantly on the SPQ but the gabapentin group improved significantly more than the trazodone group. Controlled studies are warranted to replicate these findings.

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Figures

Figure 1
Figure 1
Sleep problems questionnaire (SPQ) scores before and after medication treatment with trazodone vs. gabapentin. Matched letter pairs indicate significant (p<0.05) differences between baseline and follow-up for the trazodone (a) and gabapentin (b) groups, and between medication groups for change scores (c) and follow-up scores (d).
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