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. 2003 Oct 6;13(19):3155-9.
doi: 10.1016/s0960-894x(03)00713-3.

1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

Alexander Alanine  1 , Anne Bourson, Bernd Büttelmann, Ramanjit Gill, Marie Paule Heitz, Vincent Mutel, Emmanuel Pinard, Gerhard Trube, René Wyler
Affiliations

1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

Alexander Alanine et al. Bioorg Med Chem Lett. .

Abstract

Screening of the Roche compound depository led to the identification of (1-benzyloxy-4,5-dihydro-1H-imidazol-2-yl)-butyl amine 4, a structurally novel NR1/2B subtype selective NMDA receptor antagonist. The structure-activity relationships developed in this series resulted in the discovery of a novel class of potent and selective NMDA receptor blockers displaying activity in vivo.

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