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. 2003 Oct 6;13(19):3341-4.
doi: 10.1016/s0960-894x(03)00670-x.

Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase

T Jagadeeswar Reddy  1 , Laval Chan, Nathalie Turcotte, Melanie Proulx, Oswy Z Pereira, Sanjoy K Das, Arshad Siddiqui, Wuyi Wang, Carl Poisson, Constantin G Yannopoulos, Darius Bilimoria, Lucille L'Heureux, Hicham M A Alaoui, Nghe Nguyen-Ba
Affiliations

Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase

T Jagadeeswar Reddy et al. Bioorg Med Chem Lett. .

Abstract

Herein, we describe the structure-activity relationship (SAR) of N,N-disubstituted phenylalanine series of NS5B polymerase inhibitors of hepatitis C. The NS5B polymerase inhibitory activity of the most active compound exhibited an IC(50) of 2.7 microM.

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