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. 2003 Oct 6;13(19):3345-50.
doi: 10.1016/s0960-894x(03)00671-1.

Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues

Ayako Yamashita  1 , Emily Norton, Peter J Petersen, Beth A Rasmussen, Guy Singh, Youjin Yang, Tarek S Mansour, Douglas M Ho
Affiliations

Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues

Ayako Yamashita et al. Bioorg Med Chem Lett. .

Abstract

A series of Muraymycin analogues was synthesized. These analogues showed excellent antimicrobial activity against gram-positive organisms. These analogues also showed excellent inhibitory activity against the target peptidoglycan biosynthesis enzyme MraY, the cell membrane associated transglycosylase responsible for the formation of Lipid II.

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