Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Sep;3(9):639-49.
doi: 10.1038/nrc1164.

Origins of chromosome translocations in childhood leukaemia

Mel F Greaves  1 , Joe Wiemels
Affiliations
Review

Origins of chromosome translocations in childhood leukaemia

Mel F Greaves et al. Nat Rev Cancer. 2003 Sep.

Abstract

Chromosome translocations are often early or initiating events in leukaemogenesis, occurring prenatally in most cases of childhood leukaemia. Although these genetic changes are necessary, they are usually not sufficient to cause leukaemia. How, when and where do translocations arise? And can these insights aid our understanding of the natural history, pathogenesis and causes of leukaemia?

PubMed Disclaimer

Publication types