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Comment
. 2003 Sep;112(5):652-4.
doi: 10.1172/JCI19632.

Cardiac troponin T and familial hypertrophic cardiomyopathy: an energetic affair

Ketty Schwartz  1 , Jean-Jacques Mercadier
Affiliations
Comment

Cardiac troponin T and familial hypertrophic cardiomyopathy: an energetic affair

Ketty Schwartz et al. J Clin Invest. 2003 Sep.

Abstract

It has long been noted that while patients with familial hypertrophic cardiomyopathy due to cardiac troponin T (cTnT) mutations often suffer sudden cardiac death, they do not develop significant ventricular hypertrophy, suggesting that a distinct cellular mechanism apart from alterations in myocardial contractility is responsible. A new study has revealed that a single missense mutation in cTnT causes a striking disruption to energy metabolism, leading to cardiomyopathy.

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