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. 1976 Feb;27(2):173-81.
doi: 10.1016/0022-510x(76)90059-9.

Neurofibrillary tangles of paired helical filaments

H M Wiśniewski, H K Narang, R D Terry

Neurofibrillary tangles of paired helical filaments

H M Wiśniewski et al. J Neurol Sci. 1976 Feb.

Abstract

The abnormal aggregates of fibrillar material found in neurons in Alzheimer's disease, senile dementia, the Guam Parkinsonism-Dementia complex, Down's syndrome, and postencephalitic Parkinsonism were studied by means of tilt-stage electron microscopy and with X-ray images of scale models of a bifilar helix. The model fulfills the structural criteria established by electron microscopy. These studies showed that the "twisted tubule" which makes up the neurofibrillary tangle in many pathological situations is a bifilar helix made up of 130 A filaments.

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