Review
doi: 10.1139/h03-035.
Nitric oxide and physiologic vasodilation in human limbs: where do we go from here?
Affiliations
- PMID: 12955873
- DOI: 10.1139/h03-035
Item in Clipboard
Review
Nitric oxide and physiologic vasodilation in human limbs: where do we go from here?
Can J Appl Physiol.
2003 Jun.
Abstract
This brief review highlights human studies on the role of nitric oxide (NO) and limb vasodilation conducted at the Mayo Clinic over the last 10 years. These studies have attempted to determine whether NO is responsible for the "unexplained" limb vasodilation seen with body heating, limb ischemia, exercise, and mental stress. Our findings are placed in context with data from others, and possible future areas of study are identified.
Similar articles
-
Cutaneous interstitial nitric oxide concentration does not increase during heat stress in humans.J Appl Physiol (1985). 2001 Mar;90(3):1020-4. doi: 10.1152/jappl.2001.90.3.1020. J Appl Physiol (1985). 2001. PMID: 11181614
-
Nitric oxide and vasodilation in human limbs.J Appl Physiol (1985). 1997 Dec;83(6):1785-96. doi: 10.1152/jappl.1997.83.6.1785. J Appl Physiol (1985). 1997. PMID: 9390947 Review.
-
Sympathetic vasodilatation in human limbs.J Physiol. 2000 Aug 1;526 Pt 3:471-80. J Physiol. 2000. PMID: 10922000 Review.
-
Nitric oxide-mediated, endothelium-dependent vasodilation is selectively attenuated in the postischemic extremity.Surgery. 1993 Nov;114(5):960-7. Surgery. 1993. PMID: 8236021
-
Nitric oxide and cutaneous active vasodilation during heat stress in humans.J Appl Physiol (1985). 1998 Sep;85(3):824-9. doi: 10.1152/jappl.1998.85.3.824. J Appl Physiol (1985). 1998. PMID: 9729553 Clinical Trial.
Cited by
-
The cardiovascular effects of chronic hypoestrogenism in amenorrhoeic athletes: a critical review.Sports Med. 2004;34(9):601-27. doi: 10.2165/00007256-200434090-00004. Sports Med. 2004. PMID: 15294009 Review.
-
Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditions.Eur J Appl Physiol. 2006 Mar;96(4):363-9. doi: 10.1007/s00421-005-0085-5. Epub 2005 Nov 12. Eur J Appl Physiol. 2006. PMID: 16284786
-
Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats.Am J Physiol Regul Integr Comp Physiol. 2018 Aug 1;315(2):R191-R204. doi: 10.1152/ajpregu.00275.2017. Epub 2018 Mar 7. Am J Physiol Regul Integr Comp Physiol. 2018. PMID: 29513565 Free PMC article.
-
Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle.J Physiol. 2016 Jan 15;594(2):421-35. doi: 10.1113/JP270844. Epub 2015 Dec 16. J Physiol. 2016. PMID: 26457670 Free PMC article.
-
Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats.J Physiol. 2013 Jan 15;591(2):547-57. doi: 10.1113/jphysiol.2012.243121. Epub 2012 Oct 15. J Physiol. 2013. PMID: 23070702 Free PMC article.