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Comment
. 2003 Aug;4(2):81-3.
doi: 10.1016/s1535-6108(03)00192-2.

Turning on a dimer: new insights into MLL chimeras

Karl Hsu  1 , A Thomas Look
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Turning on a dimer: new insights into MLL chimeras

Karl Hsu et al. Cancer Cell. 2003 Aug.
Free article

Abstract

In this issue of Cancer Cell, demonstrate a novel mechanism for the oncogenic activity of MLL chimeric proteins. By providing coiled-coil or other dimerization domains, the cytoplasmic partners of MLL fusion proteins donate a platform for MLL homodimerization, allowing recruitment of accessory factors needed to activate the critical downstream targets, including selected subsets of the major HOX genes.

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