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Multicenter Study
. 2003 Oct-Nov;20(7):517-29.
doi: 10.1080/08880010390232727.

A 22-year French experience with solid tumors in children with Down syndrome

Daniel Satgé  1 , Annie J Sasco, Agnès Chompret, Daniel Orbach, Françoise Méchinaud, Brigitte Lacour, Bernard Roullet, Hélène Martelli, Christophe Bergeron, Yves Bertrand, Didier Lacombe, Yves Perel, Pascal Monteil, Brigitte Nelken, Anne-Isabelle Bertozzi, Martine Munzer, Justine Kanold, Fréderic Bernard, Michel J Vekemans, Danièle Sommelet
Affiliations
Multicenter Study

A 22-year French experience with solid tumors in children with Down syndrome

Daniel Satgé et al. Pediatr Hematol Oncol. 2003 Oct-Nov.

Abstract

Malignant solid tumors have rarely been reported in children with Down syndrome (DS) and are not well known. The authors collected from 1980 to 2001 all cases of solid tumors observed in DS patients aged from birth to 19 years within the network of the Société Française d'Oncologie Pédiatrique (SFOP). Only 21 cases were observed, with a peculiar distribution: a lack of intracranial tumors and embryonal neoplasms combined with an overrepresentation of lymphomas and germ cell tumors. The treatment of solid tumors in DS is difficult, due to physical and psychological impairments, different pharmacogenetic profile, and associated malformations.

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