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. 2003 Sep 5;17(13):1988-90.
doi: 10.1097/00002030-200309050-00020.

Drug-induced aminotransferase alterations during antiretroviral HIV post-exposure prophylaxis

Vincenzo Puro  1 , Fabio Soldani, Gabriella De Carli, Zlatan Lazarevic, Francesca Mattioli, Giuseppe Ippolito; Italian Registry of Antiretroviral Post-Exposure Prophylaxis
Affiliations

Drug-induced aminotransferase alterations during antiretroviral HIV post-exposure prophylaxis

Vincenzo Puro et al. AIDS. .

Abstract

In 655 individuals receiving HIV postexposure prophylaxis (PEP), drug-induced aminotransferase alterations were frequent and severe in the nevirapine-including regimen, rare and mild-to-moderate in other combinations, and always reversible. Grade 3-4 incidence in protease inhibitor or nevirapine PEP was 0.5 and 25.0 per 100 person-months, respectively. Apart from nevirapine, continuing PEP appears to be safe even in the case of aminotransferase alterations. The usefulness of routine monitoring of liver function during PEP could be re-considered.

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