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. 2003 Sep 5;17(13):1998-2000.
doi: 10.1097/01.aids.0000088168.01779.01.

Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma

Justin Stebbing  1 , Brian Gazzard, Ornella Flore, Claire Thomas, Adel Benlahrech, Sundhiya Mandalia, Mark Bower, Frances Gotch, Steve Patterson
Affiliations

Natural killer cells are not infected by Kaposi's sarcoma-associated herpesvirus in vivo, and natural killer cell counts do not correlate with the risk of developing Kaposi's sarcoma

Justin Stebbing et al. AIDS. .

Abstract

Although the innate immune system is implicated in the control of Kaposi's sarcoma (KS), the risk of developing KS is not associated with the nadir natural killer (NK) cell count, and NK cell counts do not significantly increase or decrease during KS resolution. KS-associated herpesvirus replication was not demonstrated in vivo or in vitro within NK cells, suggesting that NK cells do not contribute to the resolution of KS. Their role appears limited to events occurring during early infection.

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