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Case Reports
. 2003 Aug;19(8):416-20.
doi: 10.1016/S1607-551X(09)70485-1.

Combined interferon-alpha and inosiplex treatment of subacute sclerosing panencephalitis: a case report

Chy-Yuan Han  1 , Hsiu-Fen Lin, Pang-Ying Shin, Ching-Kuan Liu, Chiang-Shin Liu
Affiliations
Case Reports

Combined interferon-alpha and inosiplex treatment of subacute sclerosing panencephalitis: a case report

Chy-Yuan Han et al. Kaohsiung J Med Sci. 2003 Aug.

Abstract

Subacute sclerosing panencephalitis (SSPE) is rare in Taiwan. On admission to hospital, a 15-year-old boy was diagnosed with SSPE based on the clinical picture, electroencephalogram, cerebrospinal fluid studies, and brain biopsy. The initial clinical picture was a decline in school performance and a change in personality, followed by progressive tic-like involuntary movements and mental impairment for 8 months, then a rapidly progressive course. After the patient was treated with oral inosiplex and intraventricular interferon-alpha (IFN-alpha), his condition stabilized and the neurologic disability index score improved slightly. There were no major side effects during treatment except for a transient initial elevation of body temperature that lasted for several days. Oral inosiplex and intraventricular IFN-alpha appear to be safe and effective. Early identification and aggressive treatment of SSPE is important.

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