doi: 10.1212/01.wnl.0000078031.32904.0d.
Psychiatric adverse events during levetiracetam therapy
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- PMID: 12963770
- DOI: 10.1212/01.wnl.0000078031.32904.0d
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Psychiatric adverse events during levetiracetam therapy
Neurology.
.
Abstract
The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilepticus, whereas lamotrigine co-therapy had a protective effect. PAE were not related to the titration schedule of LEV, and certain patients seem to be biologically more vulnerable.
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