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. 2003 Sep 9;61(5):704-6.
doi: 10.1212/01.wnl.0000078031.32904.0d.

Psychiatric adverse events during levetiracetam therapy

M Mula  1 , M R Trimble, A Yuen, R S N Liu, J W A S Sander
Affiliations

Psychiatric adverse events during levetiracetam therapy

M Mula et al. Neurology. .

Abstract

The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilepticus, whereas lamotrigine co-therapy had a protective effect. PAE were not related to the titration schedule of LEV, and certain patients seem to be biologically more vulnerable.

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