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Comment
. 2003 Sep 16;100(19):10581-2.
doi: 10.1073/pnas.2035071100. Epub 2003 Sep 8.

Blocking the docking of HIV-1

Aine McKnight  1 , Robin A Weiss
Affiliations
Comment

Blocking the docking of HIV-1

Aine McKnight et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Simplified replication cycle of HIV-1. Several of the steps that can be blocked by actual or potential drugs are numbered: 1, docking to CD4, the topic of this commentary; 2, interaction with the chemokine coreceptor; 3, inhibiting fusion of the viral envelope with the cell membrane; 4, reverse transcriptase inhibitors; 5, integrase inhibitors; 6, prevention of viral transcription such as Tat antagonists; and 7, protease inhibitors. Attacking the virus with several drugs in combination has been the key to successful clinical therapy thus far.
Fig. 2.
Fig. 2.
Surface structure of HIV-1 gp120 complexed to CD4. (Left) The trimeric form of gp120 as assembled on the virus particle is shown, with soluble CD4 domains 1 and 2 (yellow) locked into the receptor binding pocket. Green shows the putative chemokine receptor binding site, and blue shows the carbohydrate moieties on this heavily glycosylated protein. (Right) A rotated and magnified view of a single gp120 surface is shown with the CD4-binding site colored yellow. [Reproduced with permission from ref. (Copyright 2002, Nature Publishing Group, www.nature.com).]
See this image and copyright information in PMC

Comment on

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