Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2003 Sep 16;100(19):10581-2.
doi: 10.1073/pnas.2035071100. Epub 2003 Sep 8.

Blocking the docking of HIV-1

Aine McKnight  1 , Robin A Weiss
Affiliations
Comment

Blocking the docking of HIV-1

Aine McKnight et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Simplified replication cycle of HIV-1. Several of the steps that can be blocked by actual or potential drugs are numbered: 1, docking to CD4, the topic of this commentary; 2, interaction with the chemokine coreceptor; 3, inhibiting fusion of the viral envelope with the cell membrane; 4, reverse transcriptase inhibitors; 5, integrase inhibitors; 6, prevention of viral transcription such as Tat antagonists; and 7, protease inhibitors. Attacking the virus with several drugs in combination has been the key to successful clinical therapy thus far.
Fig. 2.
Fig. 2.
Surface structure of HIV-1 gp120 complexed to CD4. (Left) The trimeric form of gp120 as assembled on the virus particle is shown, with soluble CD4 domains 1 and 2 (yellow) locked into the receptor binding pocket. Green shows the putative chemokine receptor binding site, and blue shows the carbohydrate moieties on this heavily glycosylated protein. (Right) A rotated and magnified view of a single gp120 surface is shown with the CD4-binding site colored yellow. [Reproduced with permission from ref. (Copyright 2002, Nature Publishing Group, www.nature.com).]
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Pomerantz, R. J. & Horn, D. L. (2003) Nat. Med. 9, 867–873. - PubMed
    1. Lin, P.-F., Blair, W., Wang, T., Spicer, T., Guo, Q., Zhou, N., Gong, Y.-F., Wang, H.-G. H., Rose, R., Yamanaka, G., et al. (2003) Proc. Natl. Acad. Sci. USA 100, 11013–11018. - PMC - PubMed
    1. Dalgleish, A. G., Beverley, P. C., Clapham, P. R., Crawford, D. H., Greaves, M. F. & Weiss, R. A. (1984) Nature 312, 763–767. - PubMed
    1. Klatzmann, D., Champagne, E., Chamaret, S., Gruest, J., Guetard, D., Hercend, T., Gluckman, J. C. & Montagnier, L. (1984) Nature 312, 767–768. - PubMed
    1. Sattentau, Q. J., Clapham, P. R., Weiss, R. A., Beverley, P. C., Montagnier, L., Alhalabi, M. F., Gluckmann, J. C. & Klatzmann, D. (1988) AIDS 2, 101–105. - PubMed

LinkOut - more resources