Review
The role of p27Kip1 in proteasome inhibitor induced apoptosis
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- PMID: 12963837
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Review
The role of p27Kip1 in proteasome inhibitor induced apoptosis
Cell Cycle.
2003 Sep-Oct.
Abstract
Proteasome inhibitors are potent inducers of cell death. The cytotoxic effect of proteasome inhibitors in general appears to be selective for proliferating cells, while quiescent cells seem to be protected. Conflicting results have been reported on the role of the CKI p27Kip1 either in promoting or inhibiting apoptosis mediated by proteasome inhibitors and other drugs. Here I discuss the role of p27Kip1 in apoptosis and chemotherapy of cancer.
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