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Comparative Study
. 2003 Sep;10(5):940-3.
doi: 10.1128/cdli.10.5.940-943.2003.

Effects of hypothermia on mortality and inflammatory responses to endotoxin-induced shock in rats

Takumi Taniguchi  1 , Hiroko Kanakura, Yasuhiro Takemoto, Ken Yamamoto
Affiliations
Comparative Study

Effects of hypothermia on mortality and inflammatory responses to endotoxin-induced shock in rats

Takumi Taniguchi et al. Clin Diagn Lab Immunol. 2003 Sep.

Abstract

We studied the effects of hypothermia on mortality rate, concentrations of tumor necrosis factor alpha and interleukin 6 in plasma, and the end products of nitric oxide (NO) in endotoxemia. It was found that moderate and mild hypothermia improved the mortality rate and attenuated cytokine responses and the elevation of the end products of NO after endotoxin injection and that these beneficial effects were similar for moderate and mild hypothermia.

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Figures

FIG. 1.
FIG. 1.
HR and SAP at baseline and after injection of endotoxin (means ± SDs). An asterisk (*) indicates a P of < 0.05 that SAP will decrease versus that for the normothermia group. bpm, beats per min.
FIG. 2.
FIG. 2.
Survival curves for the normothermia, mild hypothermia, and moderate hypothermia groups.
FIG. 3.
FIG. 3.
Changes in concentrations of TNF-α and IL-6 in plasma from baseline after endotoxin injection (means ± SDs). An asterisk (*) indicates a P of < 0.05 that TNF-α and IL-6 concentrations will increase versus those for the normothermia group.
FIG. 4.
FIG. 4.
Changes in concentrations of NOx in plasma from baseline to 4 h after endotoxin injection. An asterisk (*) indicates a P of < 0.05 that NOx concentrations will decrease versus those for the normothermia group.
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