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Clinical Trial
. 2003 Sep 15;89(6):968-70.
doi: 10.1038/sj.bjc.6601232.

Intermittent chemotherapy in metastatic androgen-independent prostate cancer

T M Beer  1 , M Garzotto, W D Henner, K M Eilers, E M Wersinger
Affiliations
Clinical Trial

Intermittent chemotherapy in metastatic androgen-independent prostate cancer

T M Beer et al. Br J Cancer. .

Abstract

Intermittent use of chemotherapy for androgen-independent prostate cancer (AIPC) instead of treatment until disease progression may reduce toxicity. We prospectively tested this approach in eight AIPC patients responding to calcitriol plus docetaxel who reached a serum prostate-specific antigen (PSA) <4 ng ml(-1). Chemotherapy was suspended until a rise in PSA>/=50% and 1 ng ml(-1). The median duration of treatment holiday was 20 weeks (13-43+weeks) and all patients retained sensitivity to re-treatment. Chemotherapy holiday was associated with an improvement of fatigue (P=0.05). Intermittent chemotherapy for AIPC is feasible and deserves further study.

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