Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Sep 18;5(19):3435-7.
doi: 10.1021/ol035178f.

Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling

Markus Kaiser  1 , Carlo Siciliano, Irmgard Assfalg-Machleidt, Michael Groll, Alexander G Milbradt, Luis Moroder
Affiliations

Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling

Markus Kaiser et al. Org Lett. .

Abstract

[structure: see text] A TMC-95A analogue extended at the C-terminus with NlePsi[COCH(2)]Gly-Ala-Ala-NH(2) was synthesized via side-chain cyclization of the linear precursor by a Suzuki cross-coupling reaction in solution to analyze the effect of additional P' residues on the inhibitory potency against yeast proteasome.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources