doi: 10.1021/ol035234c.
Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates
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- PMID: 12967299
- DOI: 10.1021/ol035234c
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Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates
Org Lett.
.
Abstract
[structure: see text] A flexible and efficient procedure has been developed for the conjugation of taxol to various arginine-based molecular transporters via the taxol C2' O-chloroacetyl derivative. The resultant taxol-transporter conjugates are highly water soluble and release free taxol with half-lives of minutes to hours depending on the pH and the linker structure.
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