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. 2003 Sep 18;5(19):3459-62.
doi: 10.1021/ol035234c.

Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates

Thorsten A Kirschberg  1 , Chris L VanDeusen, Jonathan B Rothbard, Michael Yang, Paul A Wender
Affiliations

Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates

Thorsten A Kirschberg et al. Org Lett. .

Abstract

[structure: see text] A flexible and efficient procedure has been developed for the conjugation of taxol to various arginine-based molecular transporters via the taxol C2' O-chloroacetyl derivative. The resultant taxol-transporter conjugates are highly water soluble and release free taxol with half-lives of minutes to hours depending on the pH and the linker structure.

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