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. 2003 Sep 19;68(19):7538-40.
doi: 10.1021/jo0343127.

Ruthenium-catalyzed C-H/CO/Olefin coupling reaction of N-arylpyrazoles. Extraordinary reactivity of N-arylpyrazoles toward carbonylation at C-H bonds

Taku Asaumi  1 , Naoto Chatani, Takuya Matsuo, Fumitoshi Kakiuchi, Shinji Murai
Affiliations

Ruthenium-catalyzed C-H/CO/Olefin coupling reaction of N-arylpyrazoles. Extraordinary reactivity of N-arylpyrazoles toward carbonylation at C-H bonds

Taku Asaumi et al. J Org Chem. .

Abstract

The reaction of 1-arylpyrazoles with CO and ethylene in the presence of Ru(3)(CO)(12) resulted in regioselective carbonylation at the ortho C-H bonds. While it is found that the pyrazole ring also functions as the directing group for C-H bond cleavage, the efficiency of the reaction depends on the position of the pyrazole ring.

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